12/15-Lipoxygenase Aids Wound Healing in Mice by Reducing Inflammation Through PPARγ Activation

quick Summary:

• The Proceedings of the National Academy of Sciences, Volume 122, Issue 36 (September 2025), addresses the global issue of defective wound healing.
• Research focuses on macrophage-derived 12/15-lipoxygenase (12/15-LOX,Alox15),which produces lipid mediators known as oxylipins during inflammation.
• The study explores the physiological role of these lipid mediators in resolving wound healing processes.

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indian Opinion Analysis:
Defective wound healing is a pressing global health challenge with implications for India, especially given its large population and prevalence of diabetes and other chronic conditions that delay recovery from injuries. This study adds depth to our understanding of biological mechanisms like oxylipins in inflammation resolution-an area with significant scope for medical innovation and improved healthcare outcomes. Leveraging such research could bolster India’s bioscience sector by informing therapies that address slow-healing wounds or related complications faced by millions across socio-economic spectrums.